The Prevalence of Congenital Malformation Secondary to TORCH Infection in Southeastern Romania
Anca Daniela Pinzaru1, Cristina Maria Mihai1,2, Adina Ungureanu2 and Simona Claudia Cambrea2,3
1County Clinical Emergency Hospital of Constanta, Pediatric Department, Romania; 2Faculty of Medicine, Ovidius University, Constanta, Romania; 3Clinical Infectious Diseases Hospital, Constanta, Romania
Abstract: Introduction: Considered a medical burden due to financial high consumption and leading to human losses the preventable congenital malformation determined by the TORCH system is still encountered in our activity.
Purpose: Infant mortality is considered an important medical problem for all countries. Romania has been ranked first in Europe at infant mortality for many years in a row. Looking for strategies to decrease these results is our main purpose.
Material and Method: This study was conducted in the Pediatric Department of the Clinical County Hospital of Constanta. Through a 5-year-period (March 2015- March 2020) 21 patients, aged 1-12 months were retrospectively analyzed.
Results: According to seroprevalence distribution we gathered CMV – 9 cases, syphilis -7 cases, Hepatitis B -2 cases, congenital rubella -1 case, toxoplasmosis and HIV- 1 case each. As we can notice the higher incidence is determined by cytomegalovirus (CMV), followed by congenital syphilis and hepatitis B virus.
Main complains at admission were fever (33,6%), lymphadenopathy (22,6%), seizures (12%), respiratory distress (2.5%), jaundice (5,3%), vomiting (1%), growth deficit (26%), microcephaly (4.3%), rash (15,3%). After the initial physical exam and complementary investigations, it was determined that 38% of the cases had severe neurological impairment. 25.6% were diagnosed with epilepsy. 78.5% were born preterm, and more than half were secondary to CMV infection.
Conclusion: TORCH complex has in important impact on mothers as well as on newborns and later it could affect the future adult life and health.
Keywords: Infant, Death, Infection, Malformation.