Dexamethasone 0.7 mg Implant for the Treatment of Recalcitrant Radiation Maculopathy after Proton Radiotherapy for Carcinoma of the Maxillary Sinus Pages 30-35

Justin B. Hellman1, Jose M Garcia-Gonzalez2, Shawn Lewis2 and Seenu M. Hariprasad2

1Pritzker School of Medicine, University of Chicago, Chicago, IL, USA; 2Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, USA



Abstract: Purpose: To report the efficacy of dexamethasone 0.7 mg intravitreal implant in recalcitrant radiation retinopathy. Method: Retrospective case report of a single case describing successful treatment of radiation retinopathy with dexamethasone 0.7 mg intravitreal implant following multiple failed attempts with both bevacizumab and focal laser. Results: After the first injection of 0.7 mg dexamethasone the best corrected visual acuity (BCVA) improved from 20/400 to 20/250 and central macular thickness (CMT) decreased. BCVA continued to improve after a second injection to 20/125 and remained stable through the third and fourth injection at 20/150, respectively. The intraocular pressure remained within normal limits. Conclusion: 0.7 mg dexamethasone implant showed benefit in a recalcitrant case of radiation retinopathy.

Keywords: Corticosteroids, cystoid macular edema, intravitreal implant, macular edema, Ozurdex, radiation retinopathy, steroids.