Synthesis and Physicochemical Characterization of Chitosan- Derived Prodrug Polymers with Antioxidant Activity
DOI:
https://doi.org/10.12974/2311-8717.2026.14.02Keywords:
Synthesis, Characterization, Amoxicillin, Succinic anhydride, ProdrugsAbstract
Prodrug design is a good way for drug targeting through changing the physiochemical, biopharmaceutical and pharmacokinetics properties, so prodrugs are active chemical agent undergo conversion in vivo to release the active drugs. The research apply it's lighting toward an important functional groups to permit the synthesis of prodrug polymers through a chemical reaction between chitosan and succinic anhydride by using suitable conditions (thionyl chloride as drops and 5ml of sulpheric acid (IN)) by way for one hour and at (60 Celsius) the reflux process was done for each amoxicillin and cephalexin as drugs and their detailed molecular structures of both prodrug polymers were characterized by FT-IR, 1H-NMR spectrums. XRD analysis of prodrug polymer P5 appears a sharp peak at (28.07 degree) with high intensity that matched it's crystalline nature of polymer (P6) (607) while thermal analyses (TG, DTG, DTA, DSC), TG curve show's one decomposition stage (35 Celsius) and DTG appears three stages of mass losing at three temperatures degrees (36,50,85 Celsius) while DTA curve clear's three decomposition stages. On the other hand TG curve of prodrug polymer (P6) reflect's two decomposition stages at (50,73 Celsius) DTG curve appears three temperatures (36,70,85 Celsius) and with three weight losing percentage (94.5%, 99.1%, 98.75%), so DTA curve reflects one decomposition stage at (70celsius), DSC thermogram of prodrug polymer reaction at (54.9celsius) as (P5) show's an endothermic compared with the other polymer (P6) to fix same fact of an endothermic reaction at (51celsius), while swelling ratio percentage of prodrug polymer (P6) is (217%) on the time (72 hour) as compared with the other swelling ratio polymer of prodrug (P5) is (197%) at same time (72 hour). Controlled drug release results explain the suitable time (72 hour) to achieve an increasing of controlled drug release at (PH=7.4). For prodrug polymer (P5) as (0.265 nm) as absorbance Lastly, antioxidant activity of prodrug polymer (P5) appears highly DPPH scavenged percent (97.74%) at (2.5mg/ml)as a concentration.
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